We Started LiveO2 Because Medicine Said There Was Nothing Left to Do
Mark Squibb’s son had a neurological injury. The doctors said they’d done everything they could. Mark — an engineer — decided that wasn’t good enough.
An Engineer’s Problem. An Engineer’s Solution.
Mark Squibb is an electrical engineer. Not a doctor, not a supplement marketer, not a biohacker. He thinks in systems — power, plumbing, cause and effect.
Then his family got sick. One of his children suffered a neurological injury. Mark had also been noticing his own body slowing down faster than he wanted. He went to doctors. They ran tests. They did what they could.
And then they said there was nothing left to do.
“Some people in my family got sick and then one of my kids had a neurological injury. I had been looking at oxygen for personal use because I was getting old faster than I wanted to.”— Mark Squibb, LiveO2 Founder
An engineer doesn’t accept “nothing left to do.” He asks: where’s the bottleneck? What’s the system not doing? Can it be fixed?
Mark’s research led him to the work of Manfred von Ardenne — a German physicist who spent decades studying how oxygen actually moves through the body. Von Ardenne had discovered that the problem wasn’t getting oxygen into the lungs. The real bottleneck was getting oxygen from the blood plasma into the tissues themselves.
Mark combined three principles nobody else had assembled together: exercise creates cardiovascular pressure that forces open dormant capillaries; breathing low oxygen triggers the body to push even harder; then switching to high oxygen floods the pathways the body just forced open. That combination — Adaptive Contrast — is what he built.
He built it for his family first. Then other families asked for it. Then clinics. Then athletes. Then researchers.
“Get oxygen where the body needs it. Let the body do the rest.”— Mark Squibb, LiveO2 Founder
Three Things We Know to Be True About Oxygen and the Body
The body already knows how to heal
It just needs the right conditions. Oxygen is one of those conditions. Most of what we call “chronic illness” is a delivery problem, not a broken system.
Exercise activates what rest can’t
Movement drives oxygen deeper into tissue than passive therapy alone. The cardiovascular pressure from exercise opens capillaries that stay shut when you’re sitting still.
Contrast is the mechanism
Switching between low-oxygen and high-oxygen states during exercise triggers emergency vasodilation, EPO production, and deep tissue saturation. That’s the science behind Adaptive Contrast.
20 Years. 40 Countries. One Mission.
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Built for People Who Take Their Biology Seriously
Performance Athletes
Altitude simulation without altitude. Faster recovery, higher VO₂ max, and a cardiovascular edge that standard training can’t produce.
Training & RecoveryChronic Illness & Fatigue
When standard treatments plateau. Cellular oxygen delivery for conditions — long COVID, fibromyalgia, brain fog — that resist conventional care.
Chronic ConditionsLongevity & Aging
Mitochondrial function declines with age. IHHT has been shown in peer-reviewed research to slow that decline and improve cardiovascular markers.
HealthspanClinics & Training Facilities
LiveO2 is installed in Bulletproof Labs and performance centers worldwide. Dual-user systems available for clinical and professional use.
Clinical & ProThe System Bulletproof Labs Chose
When Bulletproof Labs built out their facility, they chose LiveO2 for their permanent installation. It sits alongside cryotherapy, neurofeedback, and other serious recovery tools — not as a novelty, but as a core modality.
This is the pattern we see again and again. High-performance facilities and serious practitioners don’t use LiveO2 because it’s trendy. They use it because it works when other things stop working.
Why Adaptive Contrast Is Different From EWOT and HBOT
Standard oxygen therapy gets oxygen into the lungs. LiveO2’s Adaptive Contrast gets it into the tissues — using cardiovascular pressure and the hypoxic-hyperoxic contrast cycle to push dissolved oxygen past the congested capillaries that standard therapy can’t reach.
Mark Squibb, Engineer and Founder
Mark is an electrical engineer by training — not a doctor, not a biologist. He approaches the body the way an engineer approaches any system: find the bottleneck, fix the delivery, measure the result.
He built the first LiveO2 system for his own family after conventional medicine ran out of answers. When it worked, he shared the design. When others asked for it, he built more. LiveO2 grew not from a business plan but from a compulsion to solve a real problem.
Mark remains actively involved in system design and protocol development. The technology has evolved significantly over 20+ years — but the mission he started with hasn’t changed.
Watch Mark explain the founding story
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